Derivatives of N-phosphoamino acids and low-molecular weight peptides are of pharmaceutical interest1 and several methods for their synthesis are known. In general, esters of the amino acids or peptides were phosphorylated with phosphoryl chloride or with dialkyl or diaryl phosphoro chlorides in non-aqueous solution. 5 Previously, the method of Todd et al. 7 has been successfully applied to synthesize N-dialkylphosphoryl glycine ...
