Journal of organometallic chemistry

Palladium-catalyzed cross-coupling reaction of anilinium hypophosphite with alkenyl bromides and triflates: application to the synthesis of GABA analogs

YR Dumond, JL Montchamp

文献索引：Dumond, Yves R; Montchamp, Jean-Luc Journal of Organometallic Chemistry, 2002 , vol. 653, # 1-2 p. 252 - 260

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被引用次数: 36

摘要

Alkenyl bromides and triflates undergo palladium-catalyzed cross-coupling with anilinium hypophosphite to afford monosubstituted phosphinates (salts of alkenylphosphonous acids). The reaction is an extension of our previously reported methodology for the synthesis of aryl- and benzyl-phosphonous acids. Our preliminary results show that the best reaction conditions are observed with Pd (OAc) 2/dppp as a catalyst, in refluxing benzene or ...