Tetrahedron: Asymmetry

Baker's yeast-mediated synthesis of (R)-and (S)-heteroaryl-ethane-1, 2-diols

PV Podea, C Paizs, MI Toşa, FD Irimie

文献索引：Podea, Paula Veronica; Paizs, Csaba; Tosa, Monica Ioana; Irimie, Florin Dan Tetrahedron Asymmetry, 2008 , vol. 19, # 16 p. 1959 - 1964

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被引用次数: 16

摘要

Optically active terminal 1,2-diols are important chiral building blocks in organic synthesis with numerous applications as chiral auxiliaries or ligands for asymmetric synthesis. 1 Among the chemical methods known for their enantioselective synthesis, the asymmetric dihydroxylation of olefins or the reduction of α-hydroxy ketones protected as their silyl ethers in a CBS system 2 seems to be most common. However, these procedures suffer from inherent drawbacks. ...