Tetrahedron

A new pathway to 1, 3, 4 (2H)-isoquinolinetriones and substituted isoindolinones

J Vekemans, G Hoornaert

文献索引：Vekemans, Jozef; Hoornaert, Georges Tetrahedron, 1980 , vol. 36, p. 943 - 950

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被引用次数: 13

摘要

A new synthesis in the isoquinoline series is discussed: the reaction of appropriate benzamides and oxalyl chloride affords isoquinolinetriones along N-aroyloxamoyl chlorides. The solvent effect, the acid catalysis and the isomer distribution are accounted for. On the other hand 1-hydroxy-3-oxoisoindoline-1-carboxylates may be obtained by acid-catalyzed ring closure of N-aroyloxamates. Both cyclizations require an activating group.