Nucleosides & nucleotides

A new regio-defined synthesis of PMEA

Q Dang, V Liu, MD Erion

文献索引：Dang, Qun; Liu, Yan; Erion, Mark D. Nucleosides and Nucleotides, 1998 , vol. 17, # 8 p. 1445 - 1451

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被引用次数: 5

摘要

Abstract A new regio-defined synthesis of PMEA was developed suitable for gram-scale synthesis. Key to this synthesis was the early introduction of the phosphonomethoxy ethyl moiety and subsequent cyclization for the construction of the purine ring. This synthesis is