Tetrahedron Letters

A new Knoevenagel-type synthesis of fully substituted γ-hydroxybutenolides

C Lamberth, E Godineau, T Smejkal, S Trah

文献索引：Lamberth, Clemens; Godineau, Edouard; Smejkal, Tomas; Trah, Stephan Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4117 - 4120

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被引用次数: 4

摘要

The synthesis of fully substituted γ-hydroxybutenolides is possible by a Knoevenagel-type ring condensation of α-methyleneketones and α-ketoesters under basic conditions. This novel transformation allowed the preparation of di-aryl/heteroaryl substituted hydroxyfuranones, such as 20 and 27, which are important intermediates for pyridazine fungicides. As it turned out, a whole range of different substituents, such as alkyl, ...