Dihydropyrimidinones—a new class of anti-staphylococcal antibiotics

M Brands, R Endermann, R Gahlmann, J Krüger…

文献索引：Brands, Michael; Endermann, Rainer; Gahlmann, Reinhold; Krueger, Jochen; Raddatz, Siegfried Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 241 - 245

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被引用次数: 47

摘要

We report the synthesis and pharmacological evaluation of new derivatives of natural dipeptide antibiotic TAN-1057 A, B. In the course of this program, we identified novel analogues of the natural product that display similar antibacterial activity and showed improved tolerability.