Synlett

Rhodium-catalysed 1, 4-additions in water: Synthesis of succinic esters and β2-amino acid derivatives

KJ Wadsworth, FK Wood, CJ Chapman, CG Frost

文献索引：Wadsworth, Kelly J.; Wood, Frances K.; Chapman, Christopher J.; Frost, Christopher G. Synlett, 2004 , # 11 p. 2022 - 2024

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被引用次数: 14

摘要

At the outset of this study we chose to investigate the coupling of arylboronic acid (2b) with dimethyl itaconate (1) using water as the reaction solvent. During preliminary optimisation, the catalyst [Rh(cod)Cl] 2 (cod = cyclocta-1,5-diene) was used with sodium dodecylsulfate (SDS) as a phase transfer agent affording a 55% yield of product 3b. In the absence of SDS the yield fell to less than 10%. The addition of two equivalents of sodium carbonate increased the yield to ...