Synthesis of novel 4, 6-disubstituted quinazoline derivatives, their anti-inflammatory and anti-cancer activity (cytotoxic) against U937 leukemia cell lines

PM Chandrika, T Yakaiah, ARR Rao, B Narsaiah…

文献索引：Chandrika, P. Mani; Yakaiah; Rao, A. Raghu Ram; Narsaiah; Reddy, N. Chakra; Sridhar; Rao, J. Venkateshwara European Journal of Medicinal Chemistry, 2008 , vol. 43, # 4 p. 846 - 852

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被引用次数: 131

摘要

In view of the link between use of NSAIDs and altered cancer incidence and a growing evidence of COX-II implication in angiogenesis, a novel series of 4, 6-disubstituted quinazoline derivatives have been synthesized starting from anthranilic acid derivatives 1 through conventional methods. Initially acylation followed by cyclisation to obtain benz- oxazinones 2 which on further treatment with ammonia yielded the crucial intermediate, 2- ...