Preparation of 3, 4, 5-Trisubstituted Oxazolones by Pd-Catalyzed Coupling of N-Alkynyl tert-Butyloxycarbamates with Aryl Halides and Related Electrophiles

…, W Cui, S Xia, Y Bai, F Luo, G Zhu

文献索引：Lu, Zenghui; Cui, Weijian; Xia, Siyuan; Bai, Yihui; Luo, Fang; Zhu, Gangguo Journal of Organic Chemistry, 2012 , vol. 77, # 21 p. 9871 - 9877,7

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被引用次数: 22

摘要

A novel palladium-catalyzed approach for the assembly of 3, 4, 5-trisubstituted oxazolones has been achieved by the coupling of N-alkynyl tert-butyloxycarbamates with aryl halides and related electrophiles, which involves an oxidative addition followed by oxypalladation/ reductive elimination. The reaction provides a convenient access to diversely substituted oxazolones in satisfactory yields and shows good functional group compatibility.