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Journal of the American Chemical Society

Preparation and screening against acetylcholinesterase of a non-peptide" indexed" combinatorial library

MC Pirrung, J Chen

文献索引:Pirrung, Michael C.; Chen, Jrlung Journal of the American Chemical Society, 1995 , vol. 117, # 4 p. 1240 - 1245

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被引用次数: 131

摘要

Abstract. A combinatorial library composed from nine alcohols and six isocyanates to formally generate 54 carbamates has been designed, prepared, and screened against acetylcholinesterase from the electric eel. In order to deduce the most active member of the library, it was prepared as 15 sublibraries in which one of the reacting components was fixed and the other reactants were used as an equimolar mixture. The product mixtures were ...