Latent alkyl isocyanates as inhibitors of aldehyde dehydrogenase in vivo

HT Nagasawa, JA Elberling, DJW Goon…

文献索引：Nagasawa; Elberling; Goon; Shirota Journal of Medicinal Chemistry, 1994 , vol. 37, # 24 p. 4222 - 4226

全文：HTML全文

被引用次数: 7

摘要

On the basis of our previous observation that W-alkyl substituted chlorpropamide derivatives when administered to rats nonenzymatically eliminated n-propyl isocyanate, a known inhibitor of aldehyde dehydrogenase (AlDH), we have synthesized other latentiated n-propyl isocyanates as in vivo inhibitors of AlDH. W-Allylchlorpropamide 3 was, as expected, a potent inhibitor of hepatic AlDH in rats, as indicated by the 4-fold increase in the levels of ...