New One-Step Synthesis of Isonitriles

K Bardsley, M Hagigeorgiou, I Lengyel…

文献索引：Bardsley, Kathryn; Hagigeorgiou, Michael; Lengyel, Istvan; Cesare, Victor Synthetic Communications, 2013 , vol. 43, # 12 p. 1727 - 1733

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被引用次数: 2

摘要

A new one-step synthesis of isonitriles is described. The starting materials are a primary amine, chloroform, sodium hydride, and the phase-transfer catalyst 15-crown-5 ether, and the solvent is benzene. Five compounds are used to illustrate the features of the new synthesis: 1-adamantyl isocyanide (2a), 2-adamantyl isocyanide (2b), cis-1,8-diisocyano-p-menthane (2c), 2,4,6-trimethylphenyl isocyanide (2d), and trityl isocyanide (2e). The present ...