Chemical Synthesis and Enzymatic Testing of CMP??Sialic Acid Derivatives

…, F Freiberger, R Gerardy??Schahn, C Meier

文献索引：Wolf, Saskia; Warnecke, Svenja; Ehrit, Joerg; Freiberger, Friedrich; Gerardy-Schahn, Rita; Meier, Chris ChemBioChem, 2012 , vol. 13, # 17 p. 2605 - 2615

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被引用次数: 16

摘要

Abstract The cycloSal approach has been used in the past for the synthesis of a range of phosphorylated bioconjugates. In those reports, cycloSal nucleotides were allowed to react with different phosphate nucleophiles. With glycopyranosyl phosphates as nucleophiles, diphosphate-linked sugar nucleotides were formed. Here, cycloSal-nucleotides were used to prepare monophosphate-linked sugar nucleotides successfully in high anomeric purity ...