Tetrahedron letters

MAOS protocols for the general synthesis and lead optimization of 3, 6-disubstituted-[1, 2, 4] triazolo [4, 3-b] pyridazines

LN Aldrich, EP Lebois, LM Lewis, NT Nalywajko…

文献索引：Tetrahedron Letters, , vol. 50, # 2 p. 212 - 215

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被引用次数: 14

摘要

... Tetrahedron Letters. Volume 50, Issue 2, 14 January 2009, Pages 212–215. ... 23 μM) delivered two analogs, 22 and 24, with over a 6-fold increase in M1 inhibitory activity (M1 IC 50 = 3.99 μM and 6.64 μM, respectively) while maintaining selectivity versus M2–M5 (IC 50 >> 50 μM ...