Tetrahedron

Synthesis of novel substituted isoquinolones

…, MH Brookes, RJ Davenport, FCA Galvin, PJ Gilbert…

文献索引：Briet, Nicolas; Brookes, Michael H; Davenport, Richard J; Galvin, Frances C.A; Gilbert, Philip J; Mack, Stephen R; Sabin, Verity Tetrahedron, 2002 , vol. 58, # 29 p. 5761 - 5766

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被引用次数: 34

摘要

... 2,3-Difluorobenzylidene)(2,2-dimethoxyethyl)amine (11 g, 68 mmol) was reacted with concentrated sulfuric acid to yield the title compound as a orange solid (2.80 g, 25%); TLC R f 0.45 (50% ethylacetate/hexane); δ 1 H (300 MHz, CDCl 3 ) 9.58 (1H, s, NCHC), 8.62 (1H, d, J=7.5 Hz, NCHCH), 7.52–7.70 (3H, m, NCHCH, CHCHCF); R t =3.23 min; mass spectrum m/z 166 (M+1, 100%). 4.2.16. 6,7-Dichloroisoquinoline 2-oxide (23a). ...