Synthesis and structure–activity correlations of the cytotoxic bifunctional 1, 4-diamidoanthraquinone derivatives

HS Huang, HF Chiu, AL Lee, CL Guo…

文献索引：Huang, Hsu-Shan; Chiu, Hui-Fen; Lee, An-Long; Guo, Ching-Long; Yuan, Chun-Lung Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 23 p. 6163 - 6170

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被引用次数: 27

摘要

Anthraquinone-based compounds are attractive target for the design of new anticancer drugs. We have previously described a series of 1, 5-and 1, 4-difunctionalized anthraquinones, which exhibit different spectra of potency, together with human telomerase evaluation. The present study details the preparation of further, distinct series of regioisomeric difunctionalized amidoanthraquinone and examines their in vitro cytotoxicity ...