Pyrazole formation: Examination of kinetics, substituent effects, and mechanistic pathways
…, CL Bumgardner, WD Loehle, W Creasy
文献索引：Sloop, Joseph C.; Lechner, Brent; Washington, Gary; Bumgardner, Carl L.; Loehle, W. David; Creasy, William International Journal of Chemical Kinetics, 2008 , vol. 40, # 7 p. 370 - 383
Abstract Reaction kinetics for the condensation of 1, 3-diketones 1a–o with selected arylhydrazines (aryl= Ph, 4-NO 2 Ph, 4-CH 3 OPh, and 2, 4-diNO 2 Ph) was studied using 19 F NMR spectroscopy. Product regioselectivity is modulated by reactant ratios, substituents, and acidity. Reaction rates were found to be influenced by substituents on the diketones and on phenylhydrazines as well as by acidity of the reaction medium with rates varying as ...
