Lewis acid-assisted olefin cross-metathesis reaction: an efficient approach for the synthesis of glycosidic-pyrroloquinolinone based novel building blocks of …

L Nagarapu, HK Gaikwad, R Bantu, SR Manikonda…

文献索引：Nagarapu, Lingaiah; Gaikwad, Hanmant K.; Bantu, Rajashaker; Ganesh Kumar; Pombala, Sujitha Tetrahedron Letters, 2012 , vol. 53, # 10 p. 1287 - 1291

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被引用次数: 9

摘要

A series of glycosidic-pyrroloquinolinone based novel building blocks of camptothecin (2a– g) were synthesized via Lewis acid-assisted olefin cross-metathesis reaction using Ti (OiPr) 4 30mol% and 10mol% of Grubb's second generation catalyst with good to excellent yields. Most of these compounds exhibited significant growth inhibitory effects on all the tested cancer cell lines and three compounds (2c, 2d and 2e) showed potent cytotoxic activity.