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Tetrahedron letters

Solid-phase synthesis of a new class of oligosaccharide analogues based on azasugars

B Ruttens, J Van der Eycken

文献索引:Ruttens, Bart; Van Der Eycken, Johan Tetrahedron Letters, 2002 , vol. 43, # 12 p. 2215 - 2221

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被引用次数: 11

摘要

Our approach is based on the use of azasugars as building blocks. 5 The stereochemical diversity, conformational rigidity and numerous possibilities for derivatisation make these monomers ideal tools for the construction of oligomeric combinatorial libraries. In addition, in principle these sugar analogues can be coupled in high yield via carbamate bonds, and the lack of an anomeric centre eliminates the problem of stereocontrol during coupling. Meanwhile one can ...