Novel benzoxazole 2, 4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships.

…, H AKATSUKA, S KAWANAMI, A WATANABE…

文献索引：Arakawa, Kenji; Inamasu, Masanori; Matsumoto, Mamoru; Okumura, Kunihito; Yasuda, Kosuke; Akatsuka, Hidenori; Kawanami, Saburo; Watanabe, Akishige; Homma, Koichi; Saiga, Yutaka; Ozeki, Masakatsu; Iijima, Ikuo Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 12 p. 1984 - 1993

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被引用次数: 39

摘要

A new series of benzoxazole 2, 4-thiazolidinediones was synthesized and evaluated for hypoglycemic activity in genetically obese and diabetic yellow KK mice. 2-Arymethyl-and 2- (heteroarhylmethyl) benzoxazole derivatives showed far more potent activity than known 2, 4-thiazolidinedione derivatives such as ciglitazone, troglitazone and pioglitazone. A facile synthesis of benzoxazole 2, 4-thiazolidinediones was also established using ...