Tetrazole NK 1 receptor antagonists: the identification of an exceptionally potent orally active antiemetic compound

…, T Hubbard, C Kay, D Middlemiss, JE Mordaunt…

文献索引：Armour; Chung; Congreve; Evans; Guntrip; Hubbard; Kay; Middlemiss; Mordaunt; Pegg; Vinader; Ward; Watson Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 9 p. 1015 - 1020

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被引用次数: 47

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The medicinal chemistry strategy is described which led to the identification of GR205171, an orally active non-peptide neurokinin-1 receptor antagonist that is the most potent broad-spectrum antiemetic agent reported to date. ... The medicinal chemistry strategy is described which ...