PNA-based reagents for the direct and site-specific synthesis of thymine dimer lesions in genomic DNA
…, F Grolle, U Linne, C Haas, T Carell
文献索引：Pieck, J. Carsten; Kuch, David; Grolle, Friederike; Linne, Uwe; Haas, Clemens; Carell, Thomas Journal of the American Chemical Society, 2006 , vol. 128, # 5 p. 1404 - 1405
We thought that it would be a tremendous advantage if reagents could be created for the synthesis of a defined lesion in a defined position directly in large DNA strands or even in genomic DNA. For dT dT, the incorporation of an acetophenone into peptide nucleic acids (PNA), which are able to bind tightly and sequence-specifically to complementary DNA sequences, might allow us to achieve this goal. ... Syntheses of the acetophenone PNA building block and of the ...
