Radioiodinated flavones for in vivo imaging of β-amyloid plaques in the brain

…, K Ishibashi, M Haratake, Y Arano, H Mori…

文献索引：Ono, Masahiro; Yoshida, Naoko; Ishibashi, Kenichi; Haratake, Mamoru; Arano, Yasushi; Mori, Hiroshi; Nakayama, Morio Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7253 - 7260

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被引用次数: 76

摘要

In vivo imaging of β-amyloid (Aβ) peptide aggregates in the brain may lead to early detection of Alzheimer's disease (AD) and monitoring of the progression and effectiveness of AD treatment. The purpose of this study was to develop novel amyloid imaging agents based on flavone as a core structure. Radioiodinated flavone derivatives were designed and synthesized. The binding affinities of flavone derivatives for Aβ aggregates varied from 13 ...