N-Phenyl-N'-pyridinylureas as anticonvulsant agents

…, CP Taylor, FM Hershenson, DL Miskell

文献索引：Pavia; Lobbestael; Taylor; Hershenson; Miskell Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 854 - 861

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被引用次数: 55

摘要

A series of N-phenyl-N'-pyridinylureas wae. examined for anticonvulsant activity. Extensive structure/activity investigations revealed optimal activity in the N-(2, 6disubstituted-phenyl)- N'-(4-pyridinyl) urea series, with 37 exhibiting the best overall anticonvulsant profile. Compound 37 was effective against seizures induced by maximal electroshock but did not protect mice from clonic seizures produced by the convulsant pentylenetetrazol. The ...