Tetrahedron letters

Alternative synthesis of the chiral atypical β-adrenergicphenylethanolaminotetraline agonist SR58611A using enantioselective hydrogenation

M Devocelle, A Mortreux, F Agbossou, JR Dormoy

文献索引：Devocelle, Marc; Mortreux, Andre; Agbossou, Francine; Dormoy, Jean-Robert Tetrahedron Letters, 1999 , vol. 40, # 24 p. 4551 - 4554

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被引用次数: 49

摘要

We have developed an alternative synthesis of the atypical β-adrenergic phenylethanolaminotetraline agonist SR58611A. Two key intermediates have been synthesised involving enantioselective hydrogenation of an aminoketone and an enamide providing the corresponding amino alcohol and amide in> 96 and> 98% ee respectively.