Exploring the scope for scale-up of organic chemistry using a large batch microwave reactor
…, CM Kormos, WG Devine, NE Leadbeater
文献索引：Schmink, Jason R.; Kormos, Chad M.; Devine, William G.; Leadbeater, Nicholas E. Organic Process Research and Development, 2010 , vol. 14, # 1 p. 205 - 214
A new batch microwave reactor has been evaluated in the context of palladium-mediated transformations, condensation reactions, nucleophilic aromatic substitution reactions, and alkylations. Importantly, a linear scaling approach was taken, no changes being made to the protocol when moving from the small, developmental scale to larger scales. In some cases reactions were scaled over 18,000-fold when moving from small (0.1− 1 mmol) to large (1 ...
