Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P 2 amino acid

Y Wang, JC Huang, Z Zhou, W Yang, J Guastella…

文献索引：Wang, Yan; Huang, Jin-Chen; Zhou, Zhang-Lin; Yang, Wu; Guastella, John; Drewe, John; Cai, Sui Xiong Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1269 - 1272

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被引用次数: 22

摘要

This article describes the synthesis and biological evaluation of a series of dipeptidyl aspartyl fluoromethylketones as caspase-3 inhibitors. Structure–activity relationship (SAR) studies showed that for caspase-3 inhibition, Val is the best P2 amino acid. The SAR studies also showed that the Asp free carboxylic acid in P1 is important for caspase inhibiting activities, as well as for selectivity over other proteases.