Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives

EE Gurdal, I Durmaz, R Cetin-Atalay…

文献索引：Gurdal, Enise Ece; Durmaz, Irem; Cetin-Atalay, Rengul; Yarim, Mine Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 , vol. 29, # 2 p. 205 - 214

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被引用次数: 2

摘要

Abstract Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioamide moieties were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. In general, 4- chlorobenzhydrylpiperazine derivatives were more cytotoxic than other compounds. In ...

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4,4'-二氟二苯甲醇

27469-60-9

1-(4,4'-二氟苯甲基)哌嗪

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