Anti-HIV-1 activity of pyrryl aryl sulfone (PAS) derivatives: synthesis and SAR studies of novel esters and amides at the position 2 of the pyrrole nucleus
…, G De Martino, M La Colla, R Loddo, P La Colla
文献索引：Silvestri, Romano; Artico, Marino; La Regina, Giuseppe; De Martino, Gabriella; La Colla, Massimiliano; Loddo, Roberta; La Colla, Paolo Farmaco, 2004 , vol. 59, # 3 p. 201 - 210
A SAR study has been performed in order to evaluate how much the ester function could be a determinant for the anti-human immunodeficiency virus type-1 activity of pyrryl aryl sulfones (PASs), a potent family of non-nucleoside reverse transcriptase (RT) inhibitors discovered in the last years. Twenty-three new esters were prepared with the aim to enhance the inhibitory potency of 4a and 4c, two PAS agents endowed with good activity ( ...
