Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential

…, P Reddy, DR Reddy, E Laxman, YLN Murthy

文献索引：Kamal, Ahmed; Reddy; Reddy, D. Rajasekhar; Laxman; Murthy Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5699 - 5702

全文：HTML全文

被引用次数: 22

摘要

There is a growing interest in agents, such as pyrrolo[2,1-c][1,4]benzodiazepines (PBDs), that can recognize and bond to specific sequences of DNA. They are potential gene regulators with possible therapeutic applications in the treatment of genetic disorders, including some cancers, as selective antiinfective agents, and as probes and tools for use in molecular biology. 1 PBDs are a group of naturally occurring antitumor antibiotics, members of ...