Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors

W Shi, H Ma, Y Duan, K Aubart, Y Fang, R Zonis…

文献索引：Shi, Wei; Ma, Haikun; Duan, Yuejiao; Aubart, Kelly; Fang, Yuhong; Zonis, Rimma; Yang, Liping; Hu, Wenhao Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1060 - 1063

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被引用次数: 16

摘要

The synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives are reported. The antibacterial activities of these derivatives were evaluated to discover SAR at P1′ and P3′ positions, and most of these derivatives exhibit better in vitro antibacterial activity than existing drugs against drug-resistant clinical isolates including MRSA, PRSP, and Haemophilus influenzae.