Oxidant-free conversion of primary amines to nitriles

KNT Tseng, AM Rizzi, NK Szymczak

文献索引：Tseng, Kuei-Nin T.; Rizzi, Andrew M.; Szymczak, Nathaniel K. Journal of the American Chemical Society, 2013 , vol. 135, # 44 p. 16352 - 16355

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被引用次数: 40

摘要

An amide-derived NNN-Ru (II) hydride complex catalyzes oxidant-free, acceptorless, and chemoselective dehydrogenation of primary and secondary amines to the corresponding nitriles and imines with liberation of dihydrogen. The catalyst system tolerates oxidizable functionality and is selective for the dehydrogenation of primary amines (− CH2NH2) in the presence of amines without α-CH hydrogens.

2045-79-6

2-甲氧基苯乙胺

~48%

7035-03-2

2-甲氧基苯乙腈

~25%

~53%

~65%

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