… -Amino-1, 2, 4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1, 2, 4-benzotriazine 1, …

T Fuchs, G Chowdhury, CL Barnes…

文献索引：Fuchs; Chowdhury; Barnes; Gates Journal of Organic Chemistry, 2001 , vol. 66, # 1 p. 107 - 114

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被引用次数: 60

摘要

Tirapazamine (1) is a promising antitumor agent that selectively causes DNA damage in hypoxic tumor cells, following one-electron bioreductive activation. Surprisingly, after more than 10 years of study, the products arising from bioreductive metabolism of tirapazamine have not been completely characterized. The two previously characterized metabolites are 3- amino-1, 2, 4-benzotriazine 1-oxide (3) and 3-amino-1, 2, 4-benzotriazine (5). In this work, ...