Synthesis of hydroxy??substituted aza??analogues of antitumor anthrapyrazoles

AP Krapcho, CE Gallagher, A Hammach…

文献索引：Paul Krapcho; Gallagher, Cynthia E.; Hammach, Abdelhakim; Hacker, Miles P.; Menta, Ernesto; Oliva, Ambrogio; Domenico, Roberto Di; Re, Giovanni Da; Lotto, Andrea; Spinelli, Silvano Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 4 p. 895 - 906

全文：HTML全文

被引用次数: 7

摘要

Abstract Synthetic routes have been developed which lead to ring-hydroxylated aza- analogues of antitumor anthrapyrazoles, namely, 2, 5-bis [(aminoalkyI) amino] substituted 10- hydroxymdazolo [3, 4-fg] isoquinolin-6 (2H)-ones 1 and 7-hydroxyindazolo [4, 3-gh] isoquinolin-6 (2H)-ones 2. The regiospecific synthesis of 6, 9-dihalo-4-hydroxybenz [g] isoquinolines 3 and 4 has been accomplished. Intermediate 3 was constructed in a ...