Synthesis of novel amide derivatives with in vitro antiproliferative and cytotoxic activity

Y Liu, GY Zhang, Y Li, YN Zhang, SZ Zheng…

文献索引：Liu, Ying; Zhang, Guo-Yan; Li, Yang; Zhang, Ya-Nan; Zheng, Song-Zhi; Zhou, Zhao-Xia; An, Sheng-Ji; Jin, Ying-Hua Heteroatom Chemistry, 2013 , vol. 24, # 1 p. 9 - 17

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被引用次数: 5

摘要

ABSTRACT Some amide derivatives are highly valuable products with antiproliferative and cytotoxic bioactivity. In this paper, 12 novel amide compounds were synthesized correspondingly by boc-protection glycine, deprotection, and condensation reactions. The antiproliferative and cytotoxic activity of these compounds was also evaluated by human cervical cancer (Hela) and hepatoma carcinoma (SK-Hep-1) cancer cell lines. The assay ...