Development of a scalable process for CI-1034, an endothelin antagonist

TE Jacks, DT Belmont, CA Briggs…

文献索引：Organic Process Research and Development, , vol. 8, # 2 p. 201 - 212

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被引用次数: 40

摘要

... Organic Process Research & Development. ... Improvements to the process included using a 4-fluorobenzenesulfonate ester as a suitable substitute for the triflate group in ... Surprisingly, employing a typical procedure where the MeMgCl solution (3 M in THF) was added directly to ...