A new synthetic route to tert-butyloxycarbonylaminoacyl-4-(oxymethyl) phenylacetamidomethyl-resin, an improved support for solid-phase peptide synthesis

AR Mitchell, SBH Kent, M Engelhard…

文献索引：Mitchell,A.R. et al. Journal of Organic Chemistry, 1978 , vol. 43, p. 2845 - 2852

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被引用次数: 321

摘要

The preferred route to the aminoacylated 4-(oxymethyl) phenylacetamidomethyl-resin(- 0CH2-Pam-resin) in-volves the condensation of a Boc-aminoacyl-4-(oxymethyl) phenylacetic acid (Boc= tert-butyloxycarbonyl) with aminomethyl-resin. Aminomethyl-resin was synthesized by direct amidoalkylation of polystyrene resin to give the phthalimidomethyl- resin. The extent of reaction was monitored by IR, allowing the reaction to be stopped at ...