Abstract The synthesis of novel N 2-substituted 5-alkoxycarbonylamino-2, 4- diaminopyrimidines, 5-acylamino-2, 4-diaminopyrimidines, and 2, 4-diamino-5- ureidopyrimidines as analogues of the analgesic flupirtine is described. J. Heterocyclic Chem.,,(2012).