Synthesis and characterization of disulfide cross-linked oligonucleotides

AE Ferentz, TA Keating, GL Verdine

文献索引：Ferentz, Ann E.; Keating, Thomas A.; Verdine, Gregory L. Journal of the American Chemical Society, 1993 , vol. 115, # 20 p. 9006 - 9014

全文：HTML全文

被引用次数: 86

摘要

Abstract: Disulfide cross-linked derivatives of the “Dickerson/Drew dodecamer” 5'-d (CGCGAATTCGCG)-3'and the related decamer 5'-d (GCGAATTCGC)-3'have been synthesized, each bearing a dithiobis (ethane)(Cz) or dithiobis-(propane)(C3) cross-link at the central adenine (A). NMR and CD spectroscopy indicate that these duplexes are essentially undistorted relative to native B-DNA. However, cross-linking does confer a ...