Abstract Difluoro (trimethylsilyl) acetamides 7 have been prepared from chlorodifluoroacetamides 5 by electrochemical silylation. When condensed with carbonyl compounds, they were shown to be precursors of 2, 2-difluoro-3-hydroxyacetamides 8. N-(p- Methoxyphenyl)-2, 2-difluoro-3-hydroxy-4-methylvaleramide (8a) has been converted into the corresponding 3, 3-difluoroazetidinone 9a. This new route to 3, 3-difluoroazetidinones ...
