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Synthesis and antihypertensive activity of some 1-o-alkylglycero-3-phosphocholine derivatives

…, YL Kruglyak, MV Kiselevskii, VS Dobryanskii…

文献索引:Noskov; Shishkov; Kruglyak; Kiselevskii; Dobryanskii; Maksimtseva; Sokal'skii Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 10 p. 607 - 610

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摘要

The procedure was essentially as follows: a mixture of re- agents was dissolved in a 5 - 10-fold excess of methanol and boiled for 20 h. Then the target product III was isolated by liquid chromatography. The course of the conversion was monitored by TLC. The yield of glycerophosphocholines Ilia - llld varied within 30 - 60%. The resulting glycerophosphocholines lIIa-IIId were used in the reactions described below. Processes A, B, and C constitute a group of related reactions, ...