Tetrahedron letters

Synthesis of 5, 6-methylenedioxy-1-tetralone. An aryl grignard approach from guaiacol

RC Klix, MH Cain, AV Bhatia

文献索引：Klix, Russell C.; Cain, Michael H.; Bhatia, Ashok V. Tetrahedron Letters, 1995 , vol. 36, # 36 p. 6413 - 6414

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被引用次数: 16

摘要

A convenient synthesis of 5, 6-methylenedioxy-1-tetralone (1) is described. The main features of this synthesis are the formation of 6 via a Grignard reaction using succinic anhydride followed by selective reduction and Friedel-Crafts cyclization to generate the desired tetralone 1.