Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors

SJ Conway, JC Miller, PA Howson, BP Clark…

文献索引：Conway, Stuart J; Miller, Jacqueline C; Howson, Patrick A; Clark, Barry P; Jane, David E Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 777 - 780

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被引用次数: 20

摘要

The syntheses of a range of ring and α-substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4–10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included.