Synthesis and some pharmacological properties of bis (2-methyl-3-hydroxy-4-methoxymethyl-5-methylpyridyl) disulfide

MA Kovler, VM Avakumov, ML Lobanova…

文献索引：Kovler, M. A.; Avakumov, V. M.; Lobanova, M. L.; Alekseeva, Zh. P.; Zhukova, Z. N.; et al. Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 2 p. 79 - 81 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 2 p. 22 - 24

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摘要

The 4'-methyl ester of pyrldoxlne is reported to have antlvltamin properties [5]; pyrlditol (the dlsulflde of the pyrldoxlne thlol analog) has weak antlvltamln activity and is psychopharmacologically active. We have studied the 4'-methyl ester of pyrlditol (1) using neuropharmacologlcal screening tests [6], and compared it with pyrldltol, which we studied earlier; using the methods described in [7], we also studied its effect on the withdrawal of 4 ...