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Tetrahedron: Asymmetry

Total synthesis of (+)-myxothiazols A and Z

Y Iwaki, M Kaneko, H Akita

文献索引:Iwaki, Yuki; Kaneko, Masahiro; Akita, Hiroyuki Tetrahedron Asymmetry, 2009 , vol. 20, # 3 p. 298 - 304

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被引用次数: 7

摘要

The first synthesis of (+)-myxothiazol A 1 was achieved based on a modified Julia olefination between (3, 5R)-dimethoxy-(4R)-methyl-6-oxo-(2E)-hexenamide 3, corresponding to the left side of the final molecule, and 4-(2 ″-benzothiazolyl) sulfonylmethyl-2′-[(1′″R), 6′″- dimethylhepta-(2′″E),(4′″E)-dienyl]-2, 4′-bithiazole 6, corresponding to the right side. The synthesis of (+)-myxothiazol Z 2 was also achieved based on modified Julia ...