Selectivity control by use of near-IR for a hydrogenation process

…, C Schroyen, P Van Broeck, J Lambrechts…

文献索引：De Smet, Koen; Van Dun, Jan; Stokbroekx, Bard; Spittaels, Tom; Schroyen, Christine; Van Broeck, Peter; Lambrechts, Julien; Van Cleuvenbergen, Dirk; Smout, Guy; Dubois, Jeroen; Horvath, Andras; Verbraeken, Jurgen; Cuypers, Jef Organic Process Research and Development, 2005 , vol. 9, # 3 p. 344 - 347

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被引用次数: 10

摘要

We applied process analytical technologies to solve the problem of selectivity in the hydrogenation of 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido [1, 2-a] pyrimidin-4-one monohydrochloride (1) to (±) 3-(2-chloroethyl)-6, 7, 8, 9-tetrahydro-9-hydroxy-2-methyl-4H- pyrido [1, 2-a] pyrimidin-4-one monohydrochloride (2). We showed that both mid-IR and near-IR (NIR) were suitable for in-line analysis of the hydrogenation. We chose to use NIR ...