Tetrahedron Letters

Lipase from Carica papaya latex presents high enantioselectivity toward the resolution of prodrug (R, S)-2-bromophenylacetic acid octyl ester

…, JC Mateos, A Marty, G Sandoval, S Duquesne

文献索引：Rivera, Ivanna; Mateos, Juan Carlos; Marty, Alain; Sandoval, Georgina; Duquesne, Sophie Tetrahedron Letters, 2013 , vol. 54, # 40 p. 5523 - 5526

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被引用次数: 6

摘要

Abstract Besides the well-known papain, lipolytic activity is another interesting enzymatic activity present in latex from Carica papaya. This lipolytic activity is strongly attached to the latex solid phase, resulting in a naturally immobilized biocatalyst. In this work we describe the kinetic resolution of (R, S)-2-bromophenylacetic acid octyl ester by Carica papaya crude latex and two partially purified latex fractions. Several parameters, such as substrate ...