Synthesis of a DOTA (Gd 3+)-conjugate of proton-pump inhibitor pantoprazole for gastric wall imaging studies

GM Maharvi, AE Bharucha, AH Fauq

文献索引：Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811

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被引用次数: 1

摘要

Magnetic resonance imaging (MRI) is used to evaluate gastrointestinal (GI) structure and functions in humans. Despite filling the viscus lumen with a contrast agent, visualization of the viscus wall is limited. To overcome this limitation, we de novo synthesized a conjugate that covalently combines a Gd-based MRI contrast agent, encaged with a chelating agent (DOTA), with pantoprazole, which is a widely used proton pump inhibitor that binds to ...