Steroids

Synthesis of novel arylpyrazolo corticosteroids as potential ligands for imaging brain glucocorticoid receptors

F Wüst, KE Carlson, JA Katzenellenbogen

文献索引：Wuest, Frank; Carlson, Kathryn E.; Katzenellenbogen, John A. Steroids, 2003 , vol. 68, # 2 p. 177 - 191

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被引用次数: 34

摘要

Corticosteroids regulate a variety of essential physiological functions, such as mineral balance and stress. The great interest in these steroids, especially the glucocorticoids, stems from roles they are thought to play in neuropsychiatric disorders, such as severe depression and anxiety. The development of glucocorticoid receptor (GR) ligands which are appropriately labeled with short-lived positron-emitting radioisotopes would allow the non- ...